Serum IL-18 is a specific biomarker for Macrophage Activation Syndrome across several autoinflammatory diseases
نویسندگان
چکیده
Question IL-18 is a pro-inflammatory cytokine produced by a variety of myeloid and non-hematopoietic cells. It is canonically associated with enhancing interferon gamma (IFNg) and cytotoxicity in collaboration with IL-12p70, IL-15, or type I IFN. However, in other contexts IL-18 can promote IL-17, IL-22, or allergic responses. Macrophage Activation Syndrome (MAS) is a sepsis-like syndrome that has been associated with elevated serum IL-18 in systemic Juvenile Idiopathic Arthritis, Stills disease, and XIAP-deficiency. We sought to characterize IL-18 and associated cytokines in a cohort of patients with a variety of monogenic or complex autoinflammatory syndromes.
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